By Elizabeth Chapin

列克星敦肯塔基州. (8月. 9, 2021) — Findings from a new University of Kentucky College of Medicine 和 College of Health Sciences study add to growing evidence that resistance exercise has unique benefits for fat loss.

的 Department of Physiology 和 Center for Muscle Biology study published in the 美国实验生物学学会联合会杂志 found that resistance-like exercise regulates fat cell metabolism at a molecular level.

的 study results in mice 和 humans show that in response to mechanical loading, muscle cells release particles called extracellular vesicles that give fat cells instructions to enter fat-burning mode.

Extracellular vesicles were initially understood as a way for cells to selectively eliminate proteins, 脂质和RNA. Recently, scientists discovered that they also play a role in intercellular communication.

的 study adds a new dimension to how skeletal muscle communicates with other tissues by using extracellular vesicles, says John McCarthy, Ph.D., study author 和 associate professor in the UK Department of Physiology.

“To our knowledge, this is the first demonstration of how weight training initiates metabolic adaptations in fat tissue, which is crucial for determining whole-body metabolic outcomes,麦卡锡说. “的 ability of resistance exercise-induced extracellular vesicles to improve fat metabolism has significant clinical implications.”

McCarthy’s research team was led by post-doc Ivan Vechetti, now at the University of Nebraska, in collaboration with the Center for Muscle Biology, directed by Joseph Hamburg Endowed Professor Charlotte Peterson, Ph.D.

的 study was recently featured in 的 New York Times.

研究 reported in this publication was supported by the National Institute of Diabetes 和 Digestive 和 Kidney Diseases of the National Institutes of Health under Award Number R01DK119619. 的 content is solely the responsibility of the authors 和 does not necessarily represent the official views of the National Institutes of Health. 

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